Fibrosis/Collagen Turnover Rates

Newly synthesized tissue collagen could be measured using a stable isotope and mass spectrometry technique using heavy water (deuterium oxide)...

Newly synthesized tissue collagen could be measured using a stable isotope and mass spectrometry technique using heavy water (deuterium oxide) labeling in vivo. This method is sensitive and reproducible for measurement of collagen fractional synthesis.

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