Solutions for Pharmaceutical Researchers

Metabolic Solutions helps researchers apply stable isotope biomarkers in drug efficacy and safety studies. Our complete services include study protocol consultation, building custom test kits and a responsive analytical service compliant with current FDA Good Laboratory Practices. We are a FDA approved cGMP facility for Device Manufacturing and Drug Quality Control.

A partial list of these stable isotope biomarkers and their applications would include:

Fluid Volume Homeostasis

• Total Body Water (deuterium oxide)
• Extracellular Water (sodium bromide)

Cytochrome P450 Activity or Drug Interactions

• Erythromycin Breath Test (CYP3A4)
• Caffeine Breath Test (CYP1A2)

Measurement of Free-living Energy Expenditure

• Doubly labeled water method

Pharmacologic Modulation of Gastric Emptying Rates

• Gastric Motility Breath Test

Presence of Pathogenic Gastrointestinal Organisms

• Urea Breath Test (Helicobacter pylori)
• Small Intestinal Bacterial Overgrowth (Hydrogen Breath Test)

Hepatic Mitochondrial Function

• Methionine Breath Test

Derangements in Glucose Kinetics and Glucose Hepatic Production

• Glucose or Insulin Clamp studies with 6,6- D2-Glucose

Carbohydrate Malabsorption

• Lactose Intolerance (Hydrogen Breath Test)
• Fructose Intolerance (Hydrogen Breath Test)

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Key Industry terms: stable isotope, stable isotopes, total body water, body composition, deuterium oxide, energy expenditure, doubly labeled water, delayed gastric emptying,gastric emptying, breath test, amino acid metabolism, lipid metabolism, glucose metabolism, protein turnover, CYP3A4, cytochrome P450, sodium bromide