Solutions for Biomedical Researchers

Since 1990, Metabolic Solutions has provided an mass spectrometry service for measuring stable isotope tracers (D2O, 13C, 15N, 18O) in our state-of-the-art mass spectrometry facility. We have extensive experience in human, animal, and plant isotopic tracer studies. Our laboratory is compliant with Food and Drug Administration (FDA) current Good Laboratory Practices (cGLP) for all its assays. Our turnaround time is fast should you need a quick response to meet grant or publication deadlines.

A partial list of our established analytical assays would include:

Body Composition

• Total Body Water(D₂O or H₂¹⁸O)
• Extracellular Water(sodium bromide)

Energy Expenditure using Doubly Labeled Water

Substrate Oxidation

• Breath ¹³CO₂
• Blood ¹³CO₂

Combustion Isotope Ratio Mass Spectrometry

• ¹³C solids or liquids
• ¹⁵N solids or liquids

Glucose Metabolism

• Glucose/Insulin clamp studies (i.e., 6,6-D₂-Glucose)

Lipid Metabolism

• Glycerol kinetics
• Palmitate kinetics

Protein Metabolism

• Lipoproteins
• Other proteins

Amino Acid Metabolism

¹⁵N Urea/Ammonia End Product Studies

Metabolic Solutions, Inc., 460 Amherst Street, Nashua, NH 03063

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Key Industry terms: 13C, 15N, oxygen 18, d2o, stable isotope, stable isotopes, total body water, body composition, deuterium oxide, energy expenditure, doubly labeled water, delayed gastric emptying,gastric emptying, breath test, amino acid metabolism, lipid metabolism, protein turnover, glucose metabolism